Cosmetogenomic

Our biological models

Skin is a complex organ consisting of multiple layers of epithelial tissues but also of fibroblasts, melanocytes, adipocytes, Langerhans cells, sebaceous glands, hair follicles… Skin has several roles: body protection against pathogens, temperature and sensation control, production of vitamin D...

The epidermis, the outermost layer of the skin, provides protection against water and constitutes a barrier to environmental aggressions.

A better understanding of the skin development mechanisms and its molecular interactions between cells is now possible thanks to large-scale genomic technologies. Genomics can deepen the body of knowledge acquired on your products activities. It also helps to understand the mechanisms of certain skin disorders to develop tailored skincare products.

The choice of the biological model appears to be a key step in the implementation of the experimental design. Genex Laboratory guides you in the appropriate choice of cell or tissue type for your study.


Our technical solutions

Our technical solutions provide customized answers to your needs for cosmetic claim substantiation.

The effects of your products on human skin are:
- identified through the study of genes expression on a large scale (microarray, qPCR) and
- correlated with the protein expression of genes of interest (immunohistochemistry).


Our analysis tools

Genex Laboratory is equipped with software for:

- The analysis of expression profiles and identification of molecular mechanisms initiated after treatment of your ingredients or finished products using a correlation tool, PredictSearch™.
- Carrying out a screening with SkinProcessFinder based on the quantification of the expression of key genes (RT-qPCR) whose modulations illustrate the impact of a product at crucial points of the signaling pathways involved in skin physiology.
- Searching in silico plant extracts or molecules of interest and assist the bibliographic research for writing scientific reports via ActiveSearch™.