ENDOCRINE DISRUPTORS

An endocrine disruptor can be defined as a natural or artificial molecule mimicking the effects of a hormone and in particular sex hormones (estrogens and androgens).

Genex proposes to evaluate the potential of any active to act as endocrine disruptor.

For this purpose, there are now in vitro tests based on the expression of a marker gene under the transcriptional control of androgen or estrogen response patterns in a mammalian system.

One of the advantages of the test that we propose lies in its specialization "cutaneous" insofar as it is based on the use of human skin explants maintained in survival with a device to mimic exchanges with other tissues.

Our team focuses on identifying the physiological response of various compounds known to be potential endocrine disrupters in skin explants (epidermis/dermis or adipose tissue) in comparison with references.
Ongoing work will enable us to define marker genes to be used to predict whether a chemical compound has disruptive properties or not, followed by protein validation via an immunohistochemistry study.